The Epstein-Barr virus glycoprotein 110 carboxy-terminal tail domain is essential for lytic virus replication
نویسندگان
چکیده
منابع مشابه
The Epstein-Barr virus BMRF1 gene is essential for lytic virus replication.
The Epstein-Barr virus (EBV) BMRF1 protein is a DNA polymerase processivity factor. We have deleted the BMRF1 open reading frame from the EBV genome and assessed the DeltaBMRF1 EBV phenotype. DeltaBMRF1 viruses were replication deficient, but the wild-type phenotype could be restored by BMRF1 trans-complementation. The replication-deficient phenotype included impaired lytic DNA replication and ...
متن کاملEssential role of Rta in lytic DNA replication of Epstein-Barr virus.
Two transcription factors, ZEBRA and Rta, switch Epstein-Barr virus (EBV) from the latent to the lytic state. While ZEBRA also plays an obligatory role as an activator of replication, it is not known whether Rta is directly required for replication. Rta is dispensable for amplification of an oriLyt-containing plasmid in a transient-replication assay. Here, we assessed the requirement for Rta in...
متن کاملModulation of Epstein-Barr Virus Glycoprotein B (gB) Fusion Activity by the gB Cytoplasmic Tail Domain
UNLABELLED Epstein-Barr virus (EBV), along with other members of the herpesvirus family, requires a set of viral glycoproteins to mediate host cell attachment and entry. Viral glycoprotein B (gB), a highly conserved glycoprotein within the herpesvirus family, is thought to be the viral fusogen based on structural comparison of EBV gB and herpes simplex virus (HSV) gB with the postfusion crystal...
متن کاملEpstein-Barr Virus DNA Replication
Epstein-Barr virus (EBV) and its close relatives are the only known viruses that have two fully independent systems for replicating their genomes, one that supports virus production during active or "lytic" infection, and a second one that operates during latent stages of infection to allow the circular viral genomes to be duplicated during each cell division cycle. Although EBV's system of lyt...
متن کاملA redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication.
Epstein-Barr virus (EBV) reactivation from latency is known to be sensitive to redox regulation. The immediate-early protein Zta is a member of the basic-leucine zipper (bZIP) family of DNA binding proteins that stimulates viral and cellular transcription and nucleates a replication complex at the viral lytic origin. Zta shares with several members of the bZIP family a conserved cysteine residu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1997
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.71.5.4092-4097.1997